The two previous meetings at Anfield ended in 4-0 and 3-1 defeats for Arsene Wenger's Arsenal teams, but there is a fresh optimism around the club after a successful transfer window.
The top three places in the Premier League table look secure for Liverpool, Manchester City and Leicester City, but the fourth spot, currently occupied by Chelsea, remains tantalisingly within reach for several clubs including Carlo Ancelotti's Everton and Ole Gunnar Solskjaer's United.
IMAGES from the UEFA Champions League last 16 first leg matches played across Europe on Tuesday
Leicester City said they had a request to postpone Thursday's game against Tottenham Hotspur rejected by the league.
'In this spirit of camaraderie between professional and non-professional football, we have decided, as a team, to give up part of our Euro 2020 qualification prize money.'
Manchester City failed in an audacious transfer deadline day move for Leicester City midfielder Riyadh Mahrez, British media reported on Wednesday.
News of all that's transpired on and off the football field.
Manchester City claimed the win required to finally end Liverpool's relentless attempt to dethrone them as Premier League champions as they hit back from a goal down to crush Brighton and Hove Albion on the south coast on Sunday.
Here are five talking points from the weekend's action:
The following are talking points from the Premier League weekend:
London sides Tottenham Hotspur and Arsenal made winning starts as did fellow Premier League club Leicester City.
Tottenham striker Harry Kane said the current English Premier League season should be cancelled if not completed by the end of June due to the coronavirus pandemic. The striker explained that there is no point to extend the season till July and August as it will cause a delay in the commencement of the next season.
UEFA's FFP rules face likely changes in the wake of the CAS ruling and Mourinho said the system needs to be overhauled if it is to continue to serve its purpose which is to aim to stop clubs running big losses through spending on players.
News of all that's transpired on and off the football field
News of all that's transpired on and off the football field.
Manchester City begin a crucial week in the Premier League title race when they host Arsenal at the Etihad on Sunday.
Tottenham Hotspur strengthened their claim for a top-four finish in the Premier League with a comfortable 2-0 win over Fulham on Tuesday as Liverpool could only manage a 0-0 draw at struggling Wolverhampton Wanderers.
Manchester City moved back to second in the Premier League after a stylish 3-0 win over Everton at the Etihad Stadium on Sunday as Pep Guardiola's side responded to convincing Chelsea and Liverpool wins with a reminder of their class.
With no European prizes left to chase this season, England's top clubs are focussed on winning the Premier League title, although that goal looks beyond all but Chelsea.
Ireland striker Robbie Keane rejoined Tottenham Hotspur from Liverpool on Monday after seven disappointing months at the Anfield club.
Liverpool boss Juergen Klopp has beaten Manchester United only twice in his career and never at Old Trafford -- his worst record against any Premier League side.
A summary of Saturday's action in the Premier League.
Last week, Premier League players had launched the Players Together Fund, which primarily aims to help the NHS.
Arsenal's Aubameyang compared to Henry after his derby double
Spurs striker Bergwijn is major casualty as Netherlands trim squad
Danny Rose scored a second-half equaliser to cancel out James Milner's penalty as Tottenham Hotspur came from behind to draw 1-1 with Liverpool at White Hart Lane on Saturday.
Ole Gunnar Solskjaer continued his dream start as Manchester United caretaker manager with a 3-1 Premier League win over Huddersfield on his Old Trafford debut in the dugout on Wednesday.
Jose Mourinho's unbeaten Manchester United face the biggest test yet of their title credentials when they visit Liverpool at Anfield on Saturday -- a fixture that always has a little extra spice.
Andre Villas-Boas rarely had a good relationship with the British press and their writings over the Portuguese's handling of recent losses of Tottenham Hotspur could have gone against him.
Whatever happens in the title battle between Manchester City and Liverpool, which will go down to the final day of the season
'Solskjaer has improved morale by freeing players from the shackles with which Mourinho had bound them.' 'He has made his team a happier bunch of people,' says Suhit K Sen.
While the lack of squad-strengthening is causing consternation amongst the fans, Tottenham's squad is still young and looks more than capable of standing its ground.
A last-minute own goal gave Liverpool a 2-1 win over Tottenham Hotspur to keep them top of the Premier League but Manchester City stayed two points behind having won at Fulham. Huddersfield Town were relegated after their defeat by Crystal Palace.
Manchester United forward Anthony Martial and Tottenham Hotspur manager Mauricio Pochettino have bagged the Premier League player and manager of the month awards for September.
Manchester United are expecting a host of injured players to make their returns this month but will not rush them back into the first-team, manager Louis van Gaal said ahead of Thursday's last-16 Europa League tie against bitter rivals Liverpool. Despite having nine players currently out, including captain Wayne Rooney and defender Phil Jones, United won four games in a row prior to their shock Premier League defeat at West Bromwich Albion on Sunday. "(Antonio) Valencia is coming back, Basti (Bastian Schweinsteiger) is coming back, a lot of players shall come back in March," Van Gaal told reporters on Wednesday. "... it is hard to see whether they can cope with the rhythm of the match... Basti, for example, has only one training session under his belt. "Valencia is much more closer to being on the bench, but not to play a match."
Manchester City manager Manuel Pellegrini believes tiredness was behind their 3-0 defeat by Liverpool on Wednesday after a third successive Premier League loss put a hefty dent in their faltering title hopes.
Everton secured their English Premier League status as Dominic Calvert-Lewin scored five minutes from time to snatch a thrilling 3-2 victory over Crystal Palace after they rallied from two goals down at a rocking Goodison Park on Thursday.
'Tottenham's teamwork which has given them a chance of reeling in Leicester.'
Spurs' triumph at the Etihad Stadium moved them within two points of Premier League leaders Leicester City and kept them in second place above Arsenal on goal difference with 12 matches to play
West Brom, relegated from the Premier League last season, made 11 changes from the side that won at the weekend in the Championship and had five players -- including goalkeeper Alex Palmer -- making their debuts.
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